PCR Reagent
| Product Name | EzWay Direct ApoE Genotyping Kit |
|---|---|
| Cat. No. | K0568500 |
| Price | Please inquire |
| Size | 50T |
| Description |
|---|
Human Apolipoprotein E (ApoE) is a 34 kDa glycoprotein that plays a central role in lipid metabolism and transportation. The ApoE gene is polymorphic with three common alleles, designated E2, E3, and E4. These genes encode three ApoE protein isoforms, E2 (Cys112/Cys158), E3 (Cys112/Arg158) and E4 (Arg112/Arg158), that differ by cysteine-arginine interchanges at sites 112 and 158 in the polypeptide chain. The common ApoE isoforms exhibit variations in structure and function and are involved in several pathological processes. For instance, familial type III hyperlipoproteinemia is associated with the ApoE E2/E2 pheno/genotype, while the ApoE E4/E4 pheno/genotype is associated with high cholesterol levels, coronary artery disease, and Alzheimer’s disease. |
| Specification |
• ApoE genotyping directly from blood |
| Components |
• 2X EzWay™ Direct Hot Taq PCR MasterMix |
| Citation |
| ■ The Influence of Baseline Alzheimer's Disease Severity on Cognitive Decline and CSF Biomarkers in the NILVAD Trial Laila Abdullah, Fiona Crawford1,2, Magda Tsolaki, Anne Börjesson-Hanson4, Marcel Olde Rikkert, Florence Pasquier, Anders Wallin, Sean Kennelly, Ghania Ait-Ghezala, Daniel Paris, Suzanne Hendrix, Kaj Blennow, Brian Lawlor and Michael Mullan Front. Neurol., 06 March 2020 ■ Exploratory analyses suggest less cognitive decline with nilvadipine treatment in very mild Alzheimer’s disease subjects L Abdullah, F Crawford, H Langlois, M Tsolaki, A Börjesson-Hanson, M Olde Rikkert, F Pasquier, A Wallin, S Kennelly, S Hendrix, K Blennow, B Lawlor, M Mullan bioRxiv, 2019 ■ Enhanced capillary electrophoretic screening of Alzheimer based on direct apolipoprotein E genotyping and one-step multiplex PCR N Woo, SK Kim, Y Sun, SH Kang Journal of Chromatography B, 2018 ■ Genetics and Other Risk Factors for Past Concussions in Active-Duty Soldiers MN Dretsch, N Silverberg, AJ Gardner, WJ Panenka, T Emmerich, G Crynen, G Ait-Ghezala, H Chaytow, V Mathura, FC Crawford, GL Iverson Journal of Neurotrauma VOL. 34, NO. 4, 2017 ■ Brain‐derived neurotropic factor polymorphisms, traumatic stress, mild traumatic brain injury, and combat exposure contribute to postdeployment traumatic stress MN Dretsch, K Williams, T Emmerich, G Crynen, G Ait-Ghezala, H Chaytow, V Mathura, FC Crawford, GL Iverson Brain and Behavior, 2016; 6(1), e00392 |